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Olga E Karpicheva Selected Research

Tropomyosin

6/2021Molecular Mechanisms of the Deregulation of Muscle Contraction Induced by the R90P Mutation in Tpm3.12 and the Weakening of This Effect by BDM and W7.
10/2020Looking for Targets to Restore the Contractile Function in Congenital Myopathy Caused by Gln147Pro Tropomyosin.
6/2020Molecular Mechanisms of Muscle Weakness Associated with E173A Mutation in Tpm3.12. Troponin Ca2+ Sensitivity Inhibitor W7 Can Reduce the Damaging Effect of This Mutation.
1/2020The molecular mechanism of muscle dysfunction associated with the R133W mutation in Tpm2.2.
1/2019The molecular mechanisms of a high Ca2+-sensitivity and muscle weakness associated with the Ala155Thr substitution in Tpm3.12.
12/2018The Primary Causes of Muscle Dysfunction Associated with the Point Mutations in Tpm3.12; Conformational Analysis of Mutant Proteins as a Tool for Classification of Myopathies.
12/2018The reason for the low Ca2+-sensitivity of thin filaments associated with the Glu41Lys mutation in the TPM2 gene is "freezing" of tropomyosin near the outer domain of actin and inhibition of actin monomer switching off during the ATPase cycle.
12/2017The reason for a high Ca2+-sensitivity associated with Arg91Gly substitution in TPM2 gene is the abnormal behavior and high flexibility of tropomyosin during the ATPase cycle.
12/2017Molecular mechanisms of dysfunction of muscle fibres associated with Glu139 deletion in TPM2 gene.
3/2016Myopathy-causing Q147P TPM2 mutation shifts tropomyosin strands further towards the open position and increases the proportion of strong-binding cross-bridges during the ATPase cycle.
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Olga E Karpicheva Research Topics

Disease

6Muscle Weakness
06/2021 - 12/2017
5Muscular Diseases (Myopathy)
10/2020 - 05/2014
3Cap Myopathy
12/2018 - 12/2017
3Nemaline Myopathies (Nemaline Myopathy)
12/2018 - 08/2013
3Dilated Cardiomyopathy (Cardiomyopathy, Congestive)
08/2011 - 04/2009
2Congenital Structural Myopathies (Centronuclear Myopathy)
06/2021 - 12/2018
2Arthrogryposis
12/2018 - 12/2017
2Contracture
12/2017 - 12/2017
1Dyskinesias (Dyskinesia)
01/2016
1Hypertrophic Cardiomyopathy (Hypertrophic Obstructive Cardiomyopathy)
04/2011

Drug/Important Bio-Agent (IBA)

18TropomyosinIBA
06/2021 - 04/2009
12Myosins (Myosin)IBA
06/2021 - 09/2009
12Adenosine Triphosphatases (ATPase)IBA
06/2021 - 04/2009
4TroponinIBA
06/2021 - 07/2015
2Proteins (Proteins, Gene)FDA Link
12/2018 - 08/2013
2ActomyosinIBA
05/2014 - 08/2011
2Fluorescent Dyes (Fluorescent Probes)IBA
05/2014 - 08/2011
1troponin-tropomyosin complexIBA
06/2021
1Actins (F Actin)IBA
06/2021
1Protein Isoforms (Isoforms)IBA
12/2018
1Mutant Proteins (Protein, Mutant)IBA
12/2018
1Adenosine Triphosphate (ATP)IBA
03/2016
1Myosin SubfragmentsIBA
08/2011